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校庆系列学术活动——Dr. Xinzhong Dong

目:Identification of a mast cell specific receptor crucial for

pseudo-allergic drug reactions

间:20141117日(星期一)上午10:00

点:唐仲英科技楼三楼学术报告厅

主讲人:Dr. Xinzhong Dong

主持人:唐宗湘 教授

介:董教授1992年毕业于College of Holy Cross1998年于University of California, Los Angeles获得神经生物学博士学位,1998年至2004年于California Institute of Technology攻读博士后。现任约翰·霍普金斯大学医学院副教授,美国休斯医学研究所(HHMI) younger investigator。董教授长期从事躯体感觉(如痛觉,痒觉,触摸感觉等)形成的分子机制研究。发现并确定一类新的G蛋白偶联受体家族(Mrgprs),证明这类家族蛋白与疼痛和搔痒有关。研究结果已发表在CellNatureNature NeuroscienceNeuronNature CommunicationsPNAS 等重要国际期刊。

近年发表的相关学术论文

1. Kim Y, Chu Y, Han L, Li M, Li Z, Sun S, LaVinka PC, Tang, Z, Park K, Caterina M, Dobner R, Wei F, Dong X*. (2014) Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron 81 (4): 873-887.

2. Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, and Dong X*. (2013) Pirt functions as an endogenous regulator of TRPM8. Nature Communications July 2013.

3. Han L, Ma C, Liu Q, Weng H, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel K, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte R, Dong X*. (2013) A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 16:174-182. Covered by New York Times, Baltimore Sun, Huffington Post, Scientific American Mind, NBCnews.com, and other foreign news agencies, etc.

4. Wilson SR, GerholdK,Bifolck-Fisher A, Liu Q, Patel KN, Dong X, and Bautista DM. (2011) TRPA1 is required for histamine-independent, Mas-related G protein coupled receptor-mediated itch. Nature Neuroscience 14: 595-603.

5. Patel KN and Dong X*. (2010) An itch to be scratched. Neuron 68:334-339.

6. Guan Y, Liu Q, Tang Z, Raja SN, Anderson DJ, Dong X*. (2010) The inhibitory effect of Mas-related G protein-coupled receptors on pathological pain in mice. PNAS 107: 15933-8.

7. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng H, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, and Dong X*. (2009) Sensory neuron-specific GPCRs Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139: 1353-1365. Featured by Cell with a Preview.

8. Kim AY, Tang Z, Liu Q, Patel KN, Maag D, Geng Y, and Dong X*. (2008) Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell 133: 475-485.

9. Liu Q, Vrontou S, Rice F, Zylka MJ, Dong X* and Anderson DJ*. (2007)Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nature Neuroscience 10: 946-8 *Co-corresponding author.

 

基础医学院  

2014年11月5日

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